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OliverS – I just ran into a similar issues and found two causes:
If MS Office is loaded on your server AND you are launching IE to a MS Sharepoint Site. When the Sharepoint site launches, a bunch of MS Office .DLL’s get loaded which cause a lot of sluggishness. As a test, once you get connected to the desktop, try START / RUN / http://www.samsung.com and see if the site responds any better
HDX Flash – If you have multiple servers in your farm, disable HDX Flash on one of them and then connect to that server, see if there are any differences in the response time or overall experience.
For me, both of these issues fixed my problem and I’m now working with Citrix on a resolution.